Summation on Ovarian Hormones and Migraines

Ovarian Hormones and Migraine Headache: "A number of neurotransmitter systems and pain processing networks thought to be important to the pathogenesis of migraine headache can be modulated by estrogen and progesterone. Estrogen appears to enhance neurotransmission within the TNC in rat models of trigeminal activation, while progesterone has been shown to inhibit neurotransmission. Knowledge of the effects of ovarian hormones on the central nervous system is essential to an understanding of the pathogenesis of migraine headache."