Ovarian Hormones and Migraine Headache: "Cortical GABA levels may vary during different phases of the menstrual cycle. Epperson et al. examined cortical GABA levels with magnetic resonance spectroscopy in 9 menstruating women with premenstrual dysphoric disorder (PMDD) and 14 healthy controls. The women with PMDD demonstrated increased cortical GABA levels during the luteal phases (high progesterone/high estrogen) of the menstrual cycle when compared to the follicular phases (high estrogen/low progesterone). The control group showed the opposite results with higher cortical GABA levels within the follicular phases than the luteal phases."
This seems significant but I wish I knew what this actually means, in terms of treatment options.
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