Ovarian Hormones and Migraine Headache: "While ovarian hormones could potentially affect numerous loci within the trigeminal vascular pain pathways, their effect on the trigeminal nucleus caudalis (TNC) has been best studied. Modulation of neurotransmission within the TNC by ovarian hormones could play an important role in the pathophysiology of migraine headache. ... Progesterone may also affect neurotransmission within the TNC as well as decrease plasma extravasations in an animal model of migraine headache. Fos expression in the TNC was decreased by 42% in animals pretreated with allopregnanolone (a progesterone metabolite) after activation of the trigeminal nerve with capsaicin."
This is more like it.
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