Saturday, September 09, 2006

Behavioural and biochemical effects of tryptophan, tyrosine and phenylalanine in mice

SpringerLink - Journal Article: "Tyrosine decreased immobility in the swim test and markedly increased activity in the open field test, an action similar to the psychostimulants amphetamine and caffeine. Phenylalanine decreased immobility in the swim test, but did not affect open field activity. Thus, its behavioural effects are similar to those of an antidepressant. As expected, tryptophan increased brain tryptophan and serotonin in a dose-related fashion. Tyrosine did not alter dopamine or noradrenaline levels, while phenylalanine lowered dopamine, noradrenaline and serotonin."

Whoa, now ... phenylalanine has the behavioural effect of an anti-depressant but a blood-level effect that simulates depression?

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